Palazzo Raimondi emerged at the end of the 15th century as a truly exceptional building in the cityscape of the time. The architectural design is by Bernardino de Lera, but the inscriptions on either side of the portal celebrate the role of the client, Eliseo Raimondi, in the design of the entire building.

The white and pink limestone rusticated façade is unique in the Cremona area, and the monumental staircase, replaced after the 18th century by the current one, and the portico with columns whose capitals can be attributed to Gaspare Pedone, also the creator of the famous fireplace now preserved in the Palazzo Comunale in Cremona but originally from Palazzo Raimondi, were also unrivalled at the time. 

Among the most significant rooms is the gallery on the main floor, whose layout is due to the 20th-century renovation of the palace commissioned by the new owner, lawyer Tullio Bellomi, who commissioned Guido Bragadini (1892-1950) to create the decoration with episodes from the life of Eliseo Raimondi, in which, however, portraits of the most prominent figures of 20th-century Cremona appear. 

The complex houses the Dipartimento di Musicologia e Beni Culturali of the University of Pavia, which is home to the University Museum Collection of Musical Instruments.