Palazzo Magio Grasselli owes its name to its last owners, but it was built by the Magio family, whose presence in Cremona dates back to the 13th century. Since then, the Magio residence has been gradually expanded to incorporate neighbouring buildings, whose architectural features, dating back to the 15th century, are still preserved today.
The current layout of the building dates back to the renovation begun after 1658, at the behest of Marquis Camillo, who hired the architect Francesco Pescaroli: the modern aristocratic residence featured a large staircase, a gallery with large windows (one of which is still preserved), apartments and halls decorated by Giuseppe Natali, while the street front and the construction of the internal wing were interrupted. Work resumed in the 1760s under Camillo II: in the internal wing and antechamber, the quadrature painted by Giovanni Manfredini simulate Doric pilasters on the walls that incorporate doors and windows and open into large arches towards virtual rooms. In 1785, the large hall facing the street was also completed. In 1847, with the extinction of the Magio family, the palace passed into the ownership of the Saini family and then the Grasselli family, who lived there until 2006, when it was bequeathed to the Municipality of Cremona.