It is undoubtedly one of the oldest churches in the city and stands in an area that has been known since the Middle Ages as “La Mosa”, due to its low-lying, marshy nature.
The current sacred building is the result of the expansion of a small primitive church, which was completed in 1484 (the start date is uncertain), as attested by an inscription in the centre of the apse.
The original dedication to St. Clement was joined by that of St. Mary Magdalene due to the transfer of a statue of the saint.

The interior has a single nave with side chapels and contains valuable frescoes: noteworthy is the polyptych by Tommaso Aleni (dating back to the early 16th century) with the Adoration of the Child in the centre and the Stories of Saint Mary Magdalene and Saint Clement in the predella. Then there is Genovesino's Miracle of the Madonna Reattaching the Hand of St. John Damascene, as well as works by Vincenzo Campi, Genovesino and Luca Cattapane.